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Well, when software supports this standard, you as a user have a way to not confirm to it by setting the env variables to whatever you want, even per app. So you have two choises, either use it as is or change it.
But if software doesn’t supportthe spec, there is no choise of using it. So ons choise less.
Is it maybe the case that the setting is for allowing/disallowing you to go to sites on your local network?
For example your router controls at “192.168.1.1” (example address) or a raspberry pi with a selfhosted service like nextcloud etc.
You can probably test whether my claim is true by trying to visit your routers page with the setting enabled vs. disabled. (I am not using Chrome)
I don’t think websites have access to your local network through the browsers javascript engine, but I may be wrong.