In the case of Keepass, it is commonly said that it is best to have a database exclusively for your OTP.
For example, you have your passwords in a db called “My passwords” with an exclusive encryption password, and then another db called “My OTP’s” with its own encryption password, so if someone somehow get access to one, that person still won’t have access to the other, and therefore cannot enter your account.
In the case of Keepass, it is commonly said that it is best to have a database exclusively for your OTP.
For example, you have your passwords in a db called “My passwords” with an exclusive encryption password, and then another db called “My OTP’s” with its own encryption password, so if someone somehow get access to one, that person still won’t have access to the other, and therefore cannot enter your account.
Then use the same password for both for the sake of convenience.